KIVA is an organization that provides loans to people in third world countries to start or expand a business. I think it is a wonderful way to feel like you are making a difference in someone's life. On their website you can browse and choose the individual who you'd like to help. Your loan is paid back over time and then you'll have a credit to help someone else.
I have given KIVA gift certificates for Christmas and birthday presents and they make a unique gift for the person "who has everything".
10% of my art sold this year will be put towards KIVA loans and will be my small way of giving something back to those less fortunate.
Check out their website if you have a chance. KIVA